Hydroxylation of HIF-1: oxygen sensing at the molecular level

Physiology (Bethesda). 2004 Aug;19:176-82. doi: 10.1152/physiol.00001.2004.

Abstract

The ability to sense and respond to changes in oxygenation represents a fundamental property of all metazoan cells. The discovery of the transcription factor HIF-1 has led to the identification of protein hydroxylation as a mechanism by which changes in PO2 are transduced to effect changes in gene expression.

Publication types

  • Review

MeSH terms

  • Animals
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / metabolism*
  • Humans
  • Hydroxylation
  • Hypoxia-Inducible Factor 1
  • Hypoxia-Inducible Factor 1, alpha Subunit
  • Nuclear Proteins / genetics
  • Nuclear Proteins / metabolism*
  • Oxygen / metabolism*
  • Signal Transduction / physiology*
  • Transcription Factors*

Substances

  • DNA-Binding Proteins
  • HIF1A protein, human
  • Hypoxia-Inducible Factor 1
  • Hypoxia-Inducible Factor 1, alpha Subunit
  • Nuclear Proteins
  • Transcription Factors
  • Oxygen