A simple and rapid method for purification of triamcinolone acetonide suspension for intravitreal injection

Ophthalmic Surg Lasers Imaging. Jul-Aug 2004;35(4):350-1.

Abstract

Purification of triamcinolone acetonide suspension is important to avoid the potential toxic effects of the vehicle. The aim of this article is to describe a simple and rapid technique to remove the vehicle, instead of the long procedure described in the literature. Triamcinolone acetonide suspension was sedimented by density gradient centrifugation. In a few minutes, this new technique yielded a clear supernatant that was easily replaced by a nontoxic sterile solution. More prolonged procedures may not be convenient for unplanned treatments and may also contribute to a greater chance for contamination of the triamcinolone acetonide suspension.

MeSH terms

  • Glucocorticoids / administration & dosage
  • Glucocorticoids / isolation & purification*
  • Humans
  • Injections
  • Suspensions / chemistry
  • Triamcinolone Acetonide / administration & dosage
  • Triamcinolone Acetonide / isolation & purification*
  • Vitreous Body / drug effects

Substances

  • Glucocorticoids
  • Suspensions
  • Triamcinolone Acetonide