EGF Mediates Monocyte Chemotaxis and Macrophage Proliferation and EGF Receptor Is Expressed in Atherosclerotic Plaques

Atherosclerosis. 2004 Sep;176(1):21-6. doi: 10.1016/j.atherosclerosis.2004.04.012.

Abstract

The recruitment of peripheral monocytes to the sub-endothelial space, their development into macrophages and subsequent proliferation are critical events during atherosclerosis. Receptors for epidermal growth factor (EGF) have been identified on cells of the myeloid lineage, but a role for them in atherogenesis has yet to be described. We have identified functional EGF receptors (EGFR, ErbB1/HER-1) on peripheral blood monocytes and monocyte-derived macrophages. Uniquely, these receptors were found to mediate both chemotaxis in monocytes and macrophages and proliferation in macrophages. EGFR mRNA was detected in atherosclerotic plaques, but not in morphologically normal aortae and EGFR receptor staining co-localised with macrophage staining in these plaques. The identification of receptors for EGF on peripheral blood monocytes, macrophages and atherosclerotic lesions, together with their transduction of two functionally important cellular events, heightens the potential importance of members of the EGF super-family in atherogenesis and other chronic inflammatory processes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Aorta / immunology
  • Aorta / physiopathology
  • Arteriosclerosis / immunology*
  • Arteriosclerosis / physiopathology
  • Cell Division / immunology
  • Chemotaxis, Leukocyte / drug effects
  • Chemotaxis, Leukocyte / immunology*
  • Epidermal Growth Factor / immunology
  • Epidermal Growth Factor / metabolism
  • Epidermal Growth Factor / pharmacology*
  • ErbB Receptors / genetics*
  • ErbB Receptors / metabolism
  • Gene Expression / immunology
  • Macrophages / cytology*
  • Macrophages / physiology
  • Mitogens / immunology
  • Mitogens / metabolism
  • Mitogens / pharmacology
  • Monocytes / cytology*
  • Monocytes / physiology
  • RNA, Messenger / analysis
  • Rabbits

Substances

  • Mitogens
  • RNA, Messenger
  • Epidermal Growth Factor
  • ErbB Receptors