Value of preoperative investigations in diagnosing prosthetic joint infection: retrospective cohort study and literature review

Scand J Infect Dis. 2004;36(6-7):410-6. doi: 10.1080/00365540410015240.


The diagnosis of a prosthetic joint infection is difficult, but crucial for appropriate treatment. Scintigraphy with specific markers for infection (labelled white cells or immunoglobulin-G) has been reported as a more reliable diagnostic tool than clinical assessment (fever, fistula), laboratory studies (polynuclear neutrophil count, erythrocyte rate sedimentation, and C-reactive protein), and preoperative aspiration. In the first part of this study, we retrospectively reviewed 230 patients admitted with a suspected prosthetic joint infection, and examined the validity of the different diagnostic tools for the group as a whole and for subgroups according to the Coventry classification. In the second part, we reviewed 35 articles about preoperative evaluation of infection in prosthetic joints and compared them to our findings. Our study indicates that C-reactive protein and joint aspiration are the most useful tools to diagnose prosthetic joint infection even in situations of chronic infection (Coventry type II).

Publication types

  • Evaluation Study
  • Review

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Bacteria / isolation & purification
  • Bacterial Infections / diagnosis
  • Bacterial Infections / diagnostic imaging
  • Bacterial Infections / microbiology
  • C-Reactive Protein / analysis
  • Cohort Studies
  • Female
  • Hip Prosthesis* / adverse effects
  • Hip Prosthesis* / microbiology
  • Humans
  • Knee Prosthesis* / adverse effects
  • Knee Prosthesis* / microbiology
  • Male
  • Middle Aged
  • Predictive Value of Tests
  • Preoperative Care*
  • Prosthesis-Related Infections / diagnosis*
  • Prosthesis-Related Infections / diagnostic imaging
  • Prosthesis-Related Infections / microbiology*
  • Radiography
  • Retrospective Studies
  • Sensitivity and Specificity
  • Suction


  • C-Reactive Protein