Chron's disease, rare association with selective IgA immunodeficiency, and development of life-threatening bacterial infections

Scand J Infect Dis. 2004;36(6-7):523-4. doi: 10.1080/00365540410020190.

Abstract

Life-threatening necrotizing fasciitis and relapsing Lemierre syndrome associated with Fusobacterium necrophorum septicaemia occurred in young adults with a moderate Chron's disease and a missed profound IgA deficiency. This unexpected association of a chronic bowel inflammatory syndrome with prominent IgA abnormalities and severe bacterial infection deserves careful attention by physicians faced with young patients with Chron's disease.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Crohn Disease / complications*
  • Fasciitis, Necrotizing / microbiology*
  • Fusobacterium Infections / microbiology*
  • Fusobacterium necrophorum / pathogenicity
  • Humans
  • IgA Deficiency / complications*
  • Male
  • Peritonsillar Abscess / microbiology
  • Sepsis / microbiology*
  • Syndrome
  • Venous Thrombosis / microbiology