First BNCT treatment of a skin melanoma in Argentina: dosimetric analysis and clinical outcome

Appl Radiat Isot. 2004 Nov;61(5):1101-5. doi: 10.1016/j.apradiso.2004.05.060.


A Phase I/II protocol for treating cutaneuos melanomas with BNCT was designed in Argentina by the Comisión Nacional de Energía Atómica and the medical center Instituto Roffo. The first of a cohort of thirty planned patients was treated on October 9, 2003. This article depicts the protocol-based procedure and describes the first clinical case, treatment regime and planning, patient irradiation, retrospective dosimetric analysis and clinical outcome. Considering the low acute skin toxicity and the complete response in 21 of the 25 subcutaneous melanoma nodules treated, a second irradiation was performed in a different location of the extremity of the same patient. The corresponding clinical outcome is still under evaluation.

Publication types

  • Case Reports
  • Clinical Trial
  • Clinical Trial, Phase I
  • Clinical Trial, Phase II
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Argentina
  • Boron / blood
  • Boron / pharmacokinetics
  • Boron Compounds / pharmacokinetics
  • Boron Compounds / therapeutic use
  • Boron Neutron Capture Therapy* / methods
  • Clinical Protocols
  • Female
  • Fructose / analogs & derivatives*
  • Fructose / pharmacokinetics
  • Fructose / therapeutic use
  • Humans
  • Melanoma / metabolism
  • Melanoma / radiotherapy*
  • Melanoma / secondary
  • Middle Aged
  • Radiotherapy Planning, Computer-Assisted
  • Skin Neoplasms / metabolism
  • Skin Neoplasms / radiotherapy*
  • Skin Neoplasms / secondary
  • Treatment Outcome


  • 4-boronophenylalanine-fructose
  • Boron Compounds
  • Fructose
  • Boron