Pathogenesis of type 2 diabetes mellitus

Med Clin North Am. 2004 Jul;88(4):787-835, ix. doi: 10.1016/j.mcna.2004.04.013.


This article provides an overview of the pathogenesis of type 2 diabetes mellitus. Discussion begins by describing normal glucose homeostasis and ingestion of a typical meal and then discusses glucose homeostasis in diabetes. Topics covered include insulin secretion in type 2 diabetes mellitus and insulin resistance, the site of insulin resistance, the interaction between insulin sensitivity and secretion, the role of adipocytes in the pathogenesis of type 2 diabetes, cellular mechanisms of insulin resistance including glucose transport and phosphorylation, glycogen and synthesis,glucose and oxidation, glycolysis, and insulin signaling.

Publication types

  • Review

MeSH terms

  • Blood Glucose / analysis
  • Diabetes Mellitus, Type 2 / diagnosis
  • Diabetes Mellitus, Type 2 / drug therapy
  • Diabetes Mellitus, Type 2 / physiopathology*
  • Female
  • Glucose Intolerance
  • Humans
  • Hypoglycemic Agents / therapeutic use
  • Insulin / metabolism*
  • Insulin Resistance / physiology*
  • Insulin Secretion
  • Male
  • Phosphorylation
  • Prognosis
  • Risk Factors
  • Severity of Illness Index


  • Blood Glucose
  • Hypoglycemic Agents
  • Insulin