Diabetic neuropathies

Med Clin North Am. 2004 Jul;88(4):947-99, xi. doi: 10.1016/j.mcna.2004.04.009.


Diabetic neuropathy (DN) is a common complication of diabetes that often is associated with considerable morbidity and mortality. The epidemiology and natural history of DN is clouded with uncertainty because of confusion regarding the definition and measurement of this disorder. The recent resurgence of interest in the vascular hypothesis, oxidative stress, the neurotrophic hypothesis,and the possibility of the role of autoimmunity has opened up new avenues of investigation for therapeutic intervention. The ability to manage successfully the many different manifestations of diabetic neuropathy depends ultimately on success in uncovering the pathogenic processes underlying this disorder.

Publication types

  • Review

MeSH terms

  • Aldehyde Reductase / antagonists & inhibitors*
  • Analgesics / therapeutic use
  • Animals
  • Blood Glucose / drug effects
  • Chronic Disease
  • Diabetes Mellitus, Type 2 / complications*
  • Diabetes Mellitus, Type 2 / diagnosis
  • Diabetes Mellitus, Type 2 / drug therapy
  • Diabetic Neuropathies / epidemiology
  • Diabetic Neuropathies / etiology*
  • Diabetic Neuropathies / therapy*
  • Female
  • Humans
  • Hypoglycemic Agents / therapeutic use
  • Incidence
  • Male
  • Neural Conduction
  • Prognosis
  • Quality of Life*
  • Risk Assessment
  • Severity of Illness Index
  • Transcutaneous Electric Nerve Stimulation / methods
  • Treatment Outcome


  • Analgesics
  • Blood Glucose
  • Hypoglycemic Agents
  • Aldehyde Reductase