Association between different lipid-lowering treatment strategies and blood pressure control in the Brisighella Heart Study

Am Heart J. 2004 Aug;148(2):285-92. doi: 10.1016/j.ahj.2004.02.003.


Background: Small studies have suggested that lipid-lowering strategies, and particularly statins, could influence blood pressure (BP) control. The aim of the present study was to evaluate the effect of different lipid-lowering strategies on BP control of subjects with hypercholesterolemia who were enrolled in the prospective, population-based, longitudinal Brisighella Heart Study.

Methods: A total of 1356 subjects with total cholesterol levels >or=239 mg/dL were randomly treated for 5 years (1988-1993) with 1 of these lipid-lowering regimens: low-fat diet, cholestyramine, gemfibrozil, or simvastatin. Participants were divided at baseline into 4 quartiles according to systolic BP level and examined for the percent change in systolic and diastolic BP during the 5 years of treatment.

Results: A significant decrease in BP was observed in the 2 upper quartiles of systolic BP (>or=140 mm Hg) and was greater in subjects treated with cholesterol-lowering drugs who also had a greater reduction in plasma levels of low-density lipoprotein cholesterol. The BP decrease was greater in patients treated with statin drugs and, among those treated with antihypertensive drugs, in subjects in the fourth quartile.

Conclusion: The use of lipid-lowering measures could significantly improve BP control in subjects with both hypercholesterolemia and hypertension. The reduction in BP seems to be enhanced in subjects treated with statins.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Analysis of Variance
  • Anticholesteremic Agents / pharmacology
  • Anticholesteremic Agents / therapeutic use*
  • Antihypertensive Agents / therapeutic use
  • Blood Pressure / drug effects*
  • Cholesterol, LDL / blood
  • Cholestyramine Resin / pharmacology
  • Cholestyramine Resin / therapeutic use
  • Female
  • Gemfibrozil / pharmacology
  • Gemfibrozil / therapeutic use
  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors / pharmacology
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use*
  • Hypercholesterolemia / complications
  • Hypercholesterolemia / diet therapy
  • Hypercholesterolemia / drug therapy*
  • Hypertension / complications*
  • Hypertension / drug therapy
  • Hypertension / physiopathology
  • Male
  • Middle Aged
  • Prospective Studies
  • Simvastatin / pharmacology
  • Simvastatin / therapeutic use


  • Anticholesteremic Agents
  • Antihypertensive Agents
  • Cholesterol, LDL
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Cholestyramine Resin
  • Simvastatin
  • Gemfibrozil