Comparative antiplatelet activity of COX1 NSAIDS versus aspirin, encompassing regimen simplification and gastroprotection: a call for a controlled study

Reumatismo. Apr-Jun 2004;56(2):89-93. doi: 10.4081/reumatismo.2004.89.

Abstract

This study was conducted to assess the feasibility of COX1 NSAID substitution for aspirin for preventative therapy related to circulating anticoagulants, as manifest by inhibition of platelet aggregation. There was no difference in platelet aggregation inhibition between aspirin, naproxen, ketoprofen or diclofenac and misoprostol (in combination in the form of Arthrotec). As COX1 NSAIDs appear equivalent in platelet inhibition efficacy to aspirin, therapeutic regimens can be simplified in those individuals who require an NSAID for other problems. Further, despite its short serum halflife, Arthrotec appears as effective as an antiplatelet agent. Controlled, double blind studies of efficacy in blocking clinical events (both cardiovascular and gastrointestinal) are recommended.

Publication types

  • Comparative Study

MeSH terms

  • Anti-Inflammatory Agents, Non-Steroidal / administration & dosage
  • Anti-Inflammatory Agents, Non-Steroidal / adverse effects
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
  • Aspirin / administration & dosage
  • Aspirin / adverse effects
  • Aspirin / therapeutic use*
  • Cyclooxygenase Inhibitors / administration & dosage
  • Cyclooxygenase Inhibitors / adverse effects
  • Cyclooxygenase Inhibitors / therapeutic use*
  • Diclofenac / administration & dosage
  • Diclofenac / adverse effects
  • Diclofenac / therapeutic use*
  • Drug Combinations
  • Feasibility Studies
  • Female
  • Humans
  • Ketoprofen / administration & dosage
  • Ketoprofen / adverse effects
  • Ketoprofen / therapeutic use
  • Male
  • Middle Aged
  • Misoprostol / administration & dosage
  • Misoprostol / adverse effects
  • Misoprostol / therapeutic use*
  • Naproxen / administration & dosage
  • Naproxen / adverse effects
  • Naproxen / therapeutic use
  • Platelet Aggregation Inhibitors / administration & dosage
  • Platelet Aggregation Inhibitors / adverse effects
  • Platelet Aggregation Inhibitors / therapeutic use*
  • Stomach / drug effects
  • Time Factors

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Arthrotec
  • Cyclooxygenase Inhibitors
  • Drug Combinations
  • Platelet Aggregation Inhibitors
  • Misoprostol
  • Diclofenac
  • Naproxen
  • Ketoprofen
  • Aspirin