A listing of human tumor antigens recognized by T cells: March 2004 update

Cancer Immunol Immunother. 2005 Mar;54(3):187-207. doi: 10.1007/s00262-004-0560-6. Epub 2004 Aug 7.


The technological advances occurred in the last few years have led to a great increase in the number of tumor associated antigens (TAA) that are currently available for clinical applications. In this review we provide a comprehensive list of human tumor antigens as reported in the literature updated at February 2004. The list includes all T cell-defined epitopes, while excluding analogs or artificially modified epitopes, as well as virus-encoded and antibodies-recognized antigens. TAAs are listed in alphabetical order along with the epitope sequence and the HLA allele which restricts recognition by T cells. Data on the tissue distribution of each antigen are also provided together with an extensive bibliography that allows a rapid search for any additional information may be needed on each single antigen or epitope. Overall, the updated list is a database tool for clinicians, scientists and students who have an interest in the field of tumor immunology and immunotherapy.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Antigens, Neoplasm* / classification
  • Antigens, Neoplasm* / immunology*
  • Cloning, Molecular
  • Epitopes / chemistry
  • Histocompatibility Antigens Class I / immunology
  • Histocompatibility Antigens Class II / chemistry
  • Humans
  • Peptides / chemistry
  • T-Lymphocytes / immunology*


  • Antigens, Neoplasm
  • Epitopes
  • Histocompatibility Antigens Class I
  • Histocompatibility Antigens Class II
  • Peptides