11C-methionine PET as a prognostic marker in patients with glioma: comparison with 18F-FDG PET

Eur J Nucl Med Mol Imaging. 2005 Jan;32(1):52-9. doi: 10.1007/s00259-004-1598-6. Epub 2004 Aug 10.


Purpose: The purpose of this study was to compare the prognostic value of 11C-methionine (MET) and 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) in glioma patients.

Methods: The study population comprised 47 patients with gliomas (19 glioblastoma, 28 others). Pretreatment magnetic resonance imaging, MET PET and FDG PET were performed within a time interval of 2 weeks in all patients. The uptake ratio and standard uptake values were calculated. Univariate and multivariate analyses were done to determine significant prognostic factors. Ki-67 index was measured by immunohistochemical staining, and compared with FDG and MET uptake in glioma.

Results: Among the several clinicopathological prognostic factors, tumour pathology (glioblastoma or not), age (> or =60 or <60 years), Karnofsky performance status (KPS) (> or =70 or <70) and MET PET (higher uptake or not compared with normal cortex) were found to be significant predictors by univariate analysis. In multivariate analysis, tumour pathology, KPS and MET PET were identified as significant independent predictors. The Ki-67 proliferation index was significantly correlated with MET uptake (r=0.64), but not with FDG uptake.

Conclusion: Compared with FDG PET in glioma, MET PET was an independent significant prognostic factor and MET uptake was correlated with cellular proliferation. MET PET may be a useful biological prognostic marker in glioma patients.

Publication types

  • Comparative Study
  • Evaluation Study
  • Research Support, Non-U.S. Gov't
  • Validation Study

MeSH terms

  • Brain Neoplasms / diagnostic imaging*
  • Brain Neoplasms / mortality*
  • Brain Neoplasms / therapy
  • Female
  • Fluorodeoxyglucose F18*
  • Glioma / diagnostic imaging*
  • Glioma / mortality*
  • Glioma / therapy
  • Humans
  • Korea / epidemiology
  • Male
  • Methionine*
  • Middle Aged
  • Positron-Emission Tomography / methods
  • Positron-Emission Tomography / statistics & numerical data
  • Prevalence
  • Prognosis
  • Radiopharmaceuticals
  • Reproducibility of Results
  • Retrospective Studies
  • Risk Assessment / methods*
  • Risk Factors
  • Sensitivity and Specificity
  • Survival Analysis


  • Radiopharmaceuticals
  • Fluorodeoxyglucose F18
  • carbon-11 methionine
  • Methionine