Biphosphonate-induced radiographic changes in two pediatric patients with rheumatic diseases

Skeletal Radiol. 2004 Dec;33(12):732-6. doi: 10.1007/s00256-004-0804-8. Epub 2004 Aug 11.


Biphosphonates are now being used experimentally in children to increase bone mass, but their long-term effects remain an issue of concern. We report two cases of biphosphonate-induced radiographic changes in children with rheumatic diseases. Our experience supports the view that clinical improvement and radiographic findings after biphosphonate therapy are related to increased bone mineral density, without effects on the inflammatory process itself. Biphosphonates seem to act in rheumatic diseases by reducing bone turnover instead of improving disease activity.

Publication types

  • Case Reports

MeSH terms

  • Alendronate / pharmacology
  • Alendronate / therapeutic use*
  • Arthritis, Juvenile / diagnostic imaging
  • Arthritis, Juvenile / drug therapy*
  • Bone Density / drug effects
  • Bone Remodeling / drug effects
  • Child
  • Diphosphonates / pharmacology
  • Diphosphonates / therapeutic use*
  • Humans
  • Lupus Erythematosus, Systemic / diagnostic imaging
  • Lupus Erythematosus, Systemic / drug therapy*
  • Male
  • Osteoporosis / diagnostic imaging*
  • Osteoporosis / drug therapy
  • Radiography
  • Treatment Outcome


  • Diphosphonates
  • Alendronate