[Bone mineral density and 17 beta-estradiol correlation in postmenopausal women]

Ginecol Obstet Mex. 2004 Mar;72:95-102.
[Article in Spanish]


Background: With the increased life-expectancy reached during 20th century, women will spend a very important part of their lives in the estrogenic deficiency state accompanying menopause.

Objectives: To detect serum 17beta-estradiol levels, bone mineral density values, and to see the correlation between both parameters as well as with postmenopausal period.

Material and methods: A transversal study with ambulatory, community-dwelling postmenopausal women from Oaxaca de Juárez, Oax. was performed.

Results: We studied 70 women with spontaneous menopause, medium values were: age, 55.9 +/- 5.4 yr; menopause age, 48 +/- 3 yr; postmenopausal period, 7.9 +/- 5.3 yr; body mass index, 28.3 +/- 5.4, and serum 17beta-estradiol by radioimmunoassay, 62.78 +/- 25.83 pg/mL. Quantitative calcaneous ultrasound was used to measure bone mineral density and we found 30 women with normal level (-1.0 to 1.4 SD), 29 with osteopenia (-1.1 to -2.3 SD) and only 2 subjects with osteoporosis (-2.7 to 2.8 SD).

Conclusions: Statistical analysis shows that bone mineral density and postmenopausal period were significantly correlated (p<0.05) as well as serum 17beta-estradiol levels with postmenopausal period; nevertheless, no correlation between bone mineral density and serum 17beta-estradiol or body mass index (p>0.05) was found. On the other hand, it is remarkable high serum 17beta-estradiol levels found in this group, related with postmenopausal status. These latter results are different from those reported in the literature.

Publication types

  • Comparative Study
  • English Abstract

MeSH terms

  • Aged
  • Body Mass Index
  • Body Weight
  • Bone Density / physiology*
  • Estradiol / blood*
  • Estradiol / physiology
  • Female
  • Humans
  • Middle Aged
  • Osteoporosis, Postmenopausal / blood*
  • Osteoporosis, Postmenopausal / pathology
  • Postmenopause / physiology*


  • Estradiol