Mechanisms of neuroprotective action of vitamin D(3)

Biochemistry (Mosc). 2004 Jul;69(7):738-41. doi: 10.1023/b:biry.0000040196.65686.2f.


This review considers modern data on the mechanisms underlying the neuroprotective effect of the neurosteroid vitamin D(3) and its receptors in the nervous system. Special attention is paid to Ca2+ regulation, stimulation of neurotrophin release, interaction with reactive oxygen and nitrogen species, and neuroimmunomodulatory effects of calcitriol, the main biologically active form of vitamin D(3), in the nervous system.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Calcitriol / chemistry
  • Calcitriol / metabolism
  • Calcitriol / physiology
  • Cholecalciferol / chemistry
  • Cholecalciferol / metabolism*
  • Cholecalciferol / physiology
  • Humans
  • Molecular Structure
  • Nervous System / metabolism*
  • Nervous System Physiological Phenomena
  • Receptors, Calcitriol / metabolism
  • Receptors, Calcitriol / physiology


  • Receptors, Calcitriol
  • Cholecalciferol
  • Calcitriol