Evaluation of cardioprotective effects of recombinant soluble P-selectin glycoprotein ligand-immunoglobulin in myocardial ischemia-reperfusion injury by real-time myocardial contrast echocardiography

J Am Coll Cardiol. 2004 Aug 18;44(4):887-91. doi: 10.1016/j.jacc.2004.05.052.


Objectives: The purpose was to examine the cardioprotective effects of recombinant P-selectin glycoprotein ligand-immunoglobulin (rPSGL-Ig) in ischemia-reperfusion injury by real-time myocardial contrast echocardiography (MCE).

Background: P-selectin mediates leukocyte recruitment into areas of inflammation.

Methods: Sixteen pigs underwent 45 min of left anterior descending coronary artery occlusion followed by reperfusion and received rPSGL-Ig or vehicle. To assess changes in myocardial perfusion (A x beta), MCE was performed.

Results: After 120 min of reperfusion, A x beta in the risk area was higher (0.84 +/- 0.15 dB/s vs. 0.28 +/- 0.1 dB/s, p < 0.0001), and the infarct size was lower (30.3 +/- 12% vs. 57 +/- 14%, p = 0.002) in the rPSGL-Ig group compared with the vehicle group.

Conclusions: Recombinant PSGL-Ig improved postischemic reflow accurately detected by real-time MCE.

Publication types

  • Evaluation Study

MeSH terms

  • Animals
  • Contrast Media
  • Disease Models, Animal
  • Echocardiography
  • Membrane Glycoproteins / therapeutic use*
  • Myocardial Infarction / diagnostic imaging
  • Myocardial Infarction / prevention & control*
  • Predictive Value of Tests
  • Recombinant Proteins / therapeutic use
  • Reperfusion Injury / diagnostic imaging
  • Reperfusion Injury / prevention & control*
  • Swine


  • Contrast Media
  • Membrane Glycoproteins
  • P-selectin ligand protein
  • Recombinant Proteins