Protein synthesis, PKA, and MAP kinase are differentially involved in short- and long-term memory in rats

Behav Brain Res. 2004 Oct 5;154(2):339-43. doi: 10.1016/j.bbr.2004.03.001.


We studied the involvement of hippocampal protein synthesis-, PKA-, and MAP kinase-dependent processes in short- (STM) and long-term memory (LTM) for inhibitory avoidance task. Fifteen minutes before or immediately after training rats received intrahippocampal infusions of vehicle, the protein synthesis inhibitor anisomycin, the PKA inhibitor Rp-cAMPs or the MAPKK inhibitor PD098059. The results show that STM recruits PKA and MAPK, whereas, LTM depends on PKA activity and protein synthesis during the early post-training period.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Avoidance Learning / drug effects
  • Behavior, Animal
  • Cyclic AMP-Dependent Protein Kinases / physiology*
  • Enzyme Inhibitors / pharmacology
  • Hippocampus / drug effects
  • Hippocampus / metabolism
  • Male
  • Memory / classification*
  • Memory / drug effects
  • Memory / physiology*
  • Mitogen-Activated Protein Kinases / physiology*
  • Proteins / metabolism
  • Rats
  • Rats, Wistar
  • Reaction Time / drug effects
  • Statistics, Nonparametric
  • Time Factors


  • Enzyme Inhibitors
  • Proteins
  • Cyclic AMP-Dependent Protein Kinases
  • Mitogen-Activated Protein Kinases