The CD5+ B-cell

Int J Biochem Cell Biol. 2004 Nov;36(11):2105-11. doi: 10.1016/j.biocel.2004.05.017.


In the last two decades, many efforts have been made to better understand the biology of B-lymphoproliferative disorders through the knowledge of physiology and function of the postulated normal counterpart. The follicular mantle B-cells express a typical CD23+ IgM+ IgD+ phenotype and surround the germinal center area in secondary lymphoid organs. CD5+ B-cells with FM phenotype can be isolated from different sources and all share similar morphologic, phenotypic and functional features (small cells, scanty nucleus/cytoplasm ratio, unmutated VH genes, response to polyclonal activators but not to T independent antigens, production of "natural" antibodies). While the CD5+ B-cells predominate in fetal life, their number decreases with age. However, the CD5+ B-cells have been demonstrated to increase again in elderly both in man and mouse. This finding may explain the incidence of B-CLL and of MCL that are believed to represent the malignant transformation of the normal CD5+ B-cells, among elderly and middle aged individuals, respectively.

Publication types

  • Review

MeSH terms

  • Animals
  • B-Lymphocytes / immunology*
  • CD5 Antigens / immunology*
  • Gene Rearrangement, B-Lymphocyte, Heavy Chain / immunology
  • Humans
  • Immunoglobulin D / immunology
  • Leukemia, Lymphocytic, Chronic, B-Cell / etiology
  • Leukemia, Lymphocytic, Chronic, B-Cell / immunology*
  • Lymphoma, Mantle-Cell / etiology
  • Lymphoma, Mantle-Cell / immunology*
  • Mice
  • Receptors, IgE / immunology*


  • CD5 Antigens
  • Immunoglobulin D
  • Receptors, IgE