How much expression divergence after yeast gene duplication could be explained by regulatory motif evolution?

Trends Genet. 2004 Sep;20(9):403-7. doi: 10.1016/j.tig.2004.07.006.

Abstract

We used the yeast genome sequences of gene families, microarray profiles and regulatory motif data to test the current wisdom that there is a strong correlation between regulatory motif structure and gene expression profile. Our results suggest that duplicate genes tend to be co-expressed but the correlation between motif content and expression similarity is generally poor, only approximately 2-3% of expression variation can be explained by the motif divergence. Our observations suggest that, in addition to the cis-regulatory motif structure in the upstream region of the gene, multiple trans-acting factors in the gene network can influence the pattern of gene expression significantly.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Evolution, Molecular*
  • Gene Duplication*
  • Gene Expression Regulation, Fungal / genetics
  • Genetic Variation*
  • Genome, Fungal
  • Multigene Family
  • Phylogeny
  • Saccharomyces cerevisiae / classification
  • Saccharomyces cerevisiae / genetics*