The effectiveness of rhBMP-2 in replacing autograft: an integrated analysis of three human spine studies

Orthopedics. 2004 Jul;27(7):723-8.


In anterior lumbar spinal fusion, patients treated with rhBMP-2 on a collagen sponge carrier had statistically superior outcomes compared to patients treated with autogenous bone graft. A collagen sponge carrier should replace autogenous bone graft for this patient population.

MeSH terms

  • Blood Loss, Surgical
  • Bone Morphogenetic Protein 2
  • Bone Morphogenetic Proteins / administration & dosage
  • Bone Morphogenetic Proteins / therapeutic use*
  • Bone Transplantation*
  • Health Status Indicators
  • Humans
  • Ilium / surgery
  • Length of Stay
  • Pain Measurement
  • Spinal Fusion / methods*
  • Transforming Growth Factor beta*
  • Transplantation, Autologous


  • BMP2 protein, human
  • Bone Morphogenetic Protein 2
  • Bone Morphogenetic Proteins
  • Transforming Growth Factor beta