AID is required for c-myc/IgH chromosome translocations in vivo

Cell. 2004 Aug 20;118(4):431-8. doi: 10.1016/j.cell.2004.08.006.


Chromosome translocations between c-myc and immunoglobulin (Ig) are associated with Burkitt's lymphoma in humans and with pristane- and IL6-induced plasmacytomas in mice. These translocations frequently involve Ig switch regions, suggesting that they might be the result of aberrant Ig class switch recombination (CSR). However, a direct link between CSR and chromosome translocations has not been established. We have examined c-myc/IgH translocations in IL6 transgenic mice that are mutant for activation induced cytidine deaminase (AID), the enzyme that initiates CSR. Here we report that AID is essential for the c-myc/IgH chromosome translocations induced by IL6.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • B-Lymphocytes / metabolism
  • Cell Separation
  • Chromosomes / ultrastructure
  • Cytidine Deaminase / genetics*
  • Cytidine Deaminase / metabolism
  • Cytidine Deaminase / physiology*
  • Enzyme-Linked Immunosorbent Assay
  • Flow Cytometry
  • Immunoglobulin G / chemistry
  • Immunoglobulins / chemistry
  • Interleukin-6 / metabolism
  • Mice
  • Mice, Inbred BALB C
  • Mice, Transgenic
  • Models, Genetic
  • Polymerase Chain Reaction
  • Protein Transport
  • Proto-Oncogene Proteins c-myc / metabolism*
  • Time Factors
  • Translocation, Genetic*


  • Immunoglobulin G
  • Immunoglobulins
  • Interleukin-6
  • Proto-Oncogene Proteins c-myc
  • AICDA (activation-induced cytidine deaminase)
  • Cytidine Deaminase