Detection of antinuclear and antilaminin antibodies in autistic children who received thimerosal-containing vaccines

J Biomed Sci. Sep-Oct 2004;11(5):607-10. doi: 10.1007/BF02256125.


Autism, a neurodevelopmental disorder, may involve autoimmune pathogenesis. Since mercury is potentially a risk factor for autoimmunity, we conducted a study of mercury-induced antinuclear and antilaminin antibodies in autistic and normal children who had been pre-administered with thimerosal-containing vaccines. Laboratory analysis by different immunoassays showed that the serum level of these two autoimmune markers did not significantly differ between autistic and normal children. This finding suggests that the mercury as in thimerosal-containing vaccines is likely not related to autoimmune phenomenon in autism.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibodies, Antinuclear / blood*
  • Autistic Disorder / blood
  • Autistic Disorder / immunology*
  • Autoantibodies / blood*
  • Child
  • Humans
  • Laminin / immunology*
  • Reference Values
  • Thimerosal / immunology*
  • Thimerosal / therapeutic use
  • Vaccines / therapeutic use*


  • Antibodies, Antinuclear
  • Autoantibodies
  • Laminin
  • Vaccines
  • Thimerosal