Circulating integrins: alpha 5 beta 1, alpha 6 beta 4 and Mac-1, but not alpha 3 beta 1, alpha 4 beta 1 or LFA-1

EMBO J. 1992 Feb;11(2):405-10.

Abstract

The alpha 5 beta 1, alpha 6 beta 4 and Mac-1 integrins all participate in the endocytotic cycle. By contrast, alpha 3 beta 1, alpha 4 beta 1 and LFA-1 do so much more slowly, or not at all, in the cell lines examined. This indicates that the alpha-chains appear to determine whether an integrin cycles or not, and that alpha 5 beta 1, alpha 6 beta 4 and Mac-1 can be brought to the leading edge of a moving cell by endocytosis and recycling.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • CHO Cells
  • Cell Line
  • Cricetinae
  • Endocytosis
  • Fibronectins / physiology
  • Humans
  • Integrins / analysis
  • Integrins / physiology*
  • Lymphocyte Function-Associated Antigen-1 / analysis
  • Macrophage-1 Antigen / analysis
  • Macrophage-1 Antigen / physiology*
  • Macrophages / physiology*
  • Mice
  • Receptors, Fibronectin
  • Receptors, Immunologic / analysis
  • Receptors, Immunologic / physiology*

Substances

  • Fibronectins
  • Integrins
  • Lymphocyte Function-Associated Antigen-1
  • Macrophage-1 Antigen
  • Receptors, Fibronectin
  • Receptors, Immunologic