Acid, weakly acidic and non-acid gastro-oesophageal reflux: differences, prevalence and clinical relevance

Eur J Gastroenterol Hepatol. 2004 Sep;16(9):823-30. doi: 10.1097/00042737-200409000-00002.


In patients with gastro-oesophageal reflux disease (GORD), oesophageal symptoms and mucosal damage traditionally are related to acid-reflux episodes with pH lower than 4. Oesophageal or extra-oesophageal symptoms of GORD may also be associated with less acidic reflux (pH 4-7). New methodologies have evolved to complement pH monitoring for characterisation of less acidic gastro-oesophageal reflux. This review will focus on definition, detection, pathophysiology and symptom association of weakly acidic and non-acid reflux, in both adult and paediatric populations.

Publication types

  • Review

MeSH terms

  • Adult
  • Child
  • Diagnostic Techniques, Digestive System
  • Gastroesophageal Reflux / diagnosis
  • Gastroesophageal Reflux / epidemiology
  • Gastroesophageal Reflux / physiopathology*
  • Humans
  • Hydrogen-Ion Concentration
  • Prevalence