Clinical studies that have used the third molar extraction model for acute post-operative dental pain have demonstrated the usefulness of nonsteroidal anti-inflammatory drugs (NSAIDs) as a preoperative analgesic. Despite this evidence, the use of preoperative analgesia is still not widespread. This article reviews the preoperative use of NSAIDs for reducing postoperative dental pain and includes recommendations to implement the use of NSAIDs in patients undergoing elective surgical interventions.