Associations between dietary intake of folate and vitamins B-12 and B-6 and self-reported cognitive function and psychological well-being in Australian men and women in midlife

J Nutr Health Aging. 2004;8(4):226-32.

Abstract

Objectives: To assess dietary intake status of folate and vitamins B-12 and B-6 in 1183 middle-aged men and women, and to examine associations between dietary intake of these vitamins and self-reported cognitive function and psychological well-being.

Methods: A population-based sample of urban and rural South Australians completed questionnaires assessing demographics, background, health, and self-reported cognitive and memory functioning and psychological well-being. Usual dietary intake status was estimated using a retrospective, self-report, quantified food frequency questionnaire.

Results: About 20% of both men and women had intakes of folate that were below the Recommended Daily Intake for Australia. Vitamins B-12 and B-6 were positively related to memory functioning in men, and moderate dietary intake of folate and B-6 was associated with better memory functioning in women.

Conclusions: Vitamin B-12 and B-6 intakes may be positively related to the memory performance of middle-aged men and intakes at around the RDI are associated with better memory functioning for women. The investigation of the dose-response effects of B vitamin supplementation on cognition and mood in middle-aged men and women using objective measures of cognition and accounting for the influence of confounding factors such age and education would be informative.

MeSH terms

  • Adult
  • Aging / physiology*
  • Aging / psychology*
  • Analysis of Variance
  • Cognition / drug effects
  • Cognition / physiology*
  • Female
  • Folic Acid / administration & dosage*
  • Humans
  • Male
  • Mental Recall
  • Middle Aged
  • Nutrition Policy
  • Nutrition Surveys
  • Nutritional Requirements
  • Self Disclosure
  • South Australia
  • Surveys and Questionnaires
  • Vitamin B 12 / administration & dosage*
  • Vitamin B 6 / administration & dosage*

Substances

  • Vitamin B 6
  • Folic Acid
  • Vitamin B 12