Breast cancer incidence and use of antihypertensive medication in women

Pharmacoepidemiol Drug Saf. 2004 Aug;13(8):581-5. doi: 10.1002/pds.910.


Purpose: Breast cancer is the most common cancer in women worldwide. We attempted to investigate the association between the risk of breast cancer and use of captopril and other antihypertensive medication.

Methods: We performed a cohort study with a nested case-control analysis using the General Practitioner Research Database (GPRD) from the UK. We obtained adjusted estimates by fitting logistic regression models.

Results: The incidence rate of breast cancer in our cohort of women aged 30-79 years was 156 per 100,000 person-years. Overall, incidence of breast cancer among users of antihypertensive drugs was no different from the one among non-users (odds ratio (OR): 1.0; 95% confidence interval (CI): 0.9-1.1). Captopril was not associated with a reduced risk of breast cancer (OR: 0.9; 95%CI: 0.6-1.3).

Conclusions: We did not find any clear association between antihypertensive drugs and risk of breast cancer. Similarly, captopril was not associated with a reduced risk of breast cancer risk.

MeSH terms

  • Adult
  • Age Distribution
  • Aged
  • Antihypertensive Agents / adverse effects*
  • Breast Neoplasms / chemically induced*
  • Breast Neoplasms / epidemiology
  • Captopril / adverse effects
  • Case-Control Studies
  • Female
  • Humans
  • Incidence
  • Logistic Models
  • Medical Records Systems, Computerized
  • Middle Aged
  • Registries
  • United Kingdom / epidemiology


  • Antihypertensive Agents
  • Captopril