[Effect of thyroxin and thymalin on proliferation and apoptosis of thymocytes in rats after thyroidectomy]

Iu Ia Hrinevych; H D Bendiuh; N M Khranovs'ka; Iu M Bilokin'; O M Ostapenko

[Effect of thyroxin and thymalin on proliferation and apoptosis of thymocytes in rats after thyroidectomy]

Fiziol Zh (1994). 2004;50(3):39-43.

[Article in Ukrainian]

Authors

Iu Ia Hrinevych, H D Bendiuh, N M Khranovs'ka, Iu M Bilokin', O M Ostapenko

PMID: 15320428

Abstract

It is found that 3 months after removal of thyroid gland in rats, a suppression of thymic endocrine function, loss of weight and cellularity occurs. These changes are mainly caused by a weakening of index of proliferative activity. In animals that postoperatively received substitutive thyroxin hormonotherapy and courses of thymulin these disorders don't occur or they are not expressed significantly.

Publication types

English Abstract

MeSH terms

Animals
Apoptosis / drug effects*
Body Weight / drug effects
Cell Proliferation / drug effects
Hormone Replacement Therapy*
Male
Organ Size / drug effects
Rats
Thymus Gland / drug effects*
Thymus Gland / pathology
Thymus Hormones / pharmacology*
Thymus Hormones / therapeutic use
Thyroidectomy*
Thyroxine / pharmacology*
Thyroxine / therapeutic use

Substances

Thymus Hormones
thymalin
Thyroxine