Retracted: Effects of Vitamin K2 on Osteoporosis

Curr Pharm Des. 2004;10(21):2557-76. doi: 10.2174/1381612043383782.


The article entitled “Effects of Vitamin K2 on Osteoporosis, published in Curr Pharm Des 2004; 10(21): 2557-76, by Iwamoto J, Takeda T and Sato Y.” has been retracted by the Editorial office of the journal Current Pharmaceutical Design, as the text, data and some figures used/referred in this review article are from sources which have been retracted or under investigation on the basis of data fabrication and falsification, authorship misconduct, duplicate publication, unethical research practices, text recycling/self-plagiarism, and unresolved concerns about data integrity and research conduct. The authors were informed of this complaint and were requested to give justification on the matter in their defense. However, no reply was received from their side in this regard. Some sources that have been retracted are as follows:

Reference: 1. Iwamoto J, Takeda T, Ichimura S. Combined treatment with vitamin K2 and bisphosphonate in postmenopausal women with osteoporosis. Yonsei Med J 2003; 44: 751-6. Available at:

2. Sato Y, Honda Y, Kuno H, Oizumi K. Menatetrenone ameliorates osteopenia in disuse-affected limbs of vitamin D- and K-deficient stroke patients. Bone 1998; 23: 291-6. Available at:

3. Sato Y, Honda Y, Kaji M, Asoh T, Hosokawa K, Kondo I, et al. Amelioration of osteoporosis by menatetrenone in elderly female Parkinson's disease patients with vitamin D deficiency. Bone 2002; 31: 114-8. Available at: 12110423/.

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Publication types

  • Review
  • Retracted Publication

MeSH terms

  • Animals
  • Calcium / deficiency
  • Cholecalciferol / therapeutic use
  • Drug Therapy, Combination
  • Female
  • Hip Fractures / drug therapy
  • Humans
  • Liver Diseases / complications
  • Male
  • Osteocalcin / metabolism
  • Osteoporosis / chemically induced
  • Osteoporosis / drug therapy*
  • Osteoporosis / etiology
  • Osteoporosis, Postmenopausal / drug therapy
  • Space Flight
  • Vitamin K 2 / therapeutic use*
  • Weightlessness / adverse effects


  • Osteocalcin
  • Vitamin K 2
  • Cholecalciferol
  • Calcium