A matter of focus: monoaminergic modulation of stimulus coding in mammalian sensory networks

Curr Opin Neurobiol. 2004 Aug;14(4):488-95. doi: 10.1016/j.conb.2004.06.007.


Although the presence of neuromodulators in mammalian sensory systems has been noted for some time, a groundswell of evidence has now begun to document the scope of these regulatory mechanisms in several sensory systems, highlighting the importance of neuromodulation in shaping feature extraction at all levels of neural processing. The emergence of more sophisticated models of sensory encoding and of the interaction between sensory and regulatory regions of the brain will challenge sensory neurobiologists to further incorporate a concept of sensory network function that is contingent on neuromodulatory and behavioral state.

Publication types

  • Review

MeSH terms

  • Action Potentials / physiology
  • Animals
  • Biogenic Monoamines / physiology*
  • Brain / cytology
  • Brain / physiology*
  • Humans
  • Nerve Net / cytology
  • Nerve Net / physiology*
  • Neural Inhibition / physiology
  • Neurotransmitter Agents / physiology*
  • Norepinephrine / physiology
  • Sensation / physiology*
  • Serotonin / physiology
  • Signal Transduction / physiology


  • Biogenic Monoamines
  • Neurotransmitter Agents
  • Serotonin
  • Norepinephrine