Abstract
Prairie dogs (Cynomys spp.) are highly susceptible to Yersinia pestis and significant reservoirs of plague for humans in the western United States. A recombinant raccoon poxvirus, expressing the F1 antigen of Y. pestis, was incorporated into a palatable bait and offered to 18 black-tailed prairie dogs (Cynomys ludovicianus) for voluntary consumption; 18 negative control animals received placebo baits. Antibody titers against Y. pestis F1 antigen increased significantly (P < 0.01) in vaccinees, and their survival was significantly higher upon challenge with Y. pestis than that of negative controls (P < 0.01).
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Administration, Oral
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Animals
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Antibodies, Bacterial / blood
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Bacterial Proteins / genetics
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Bacterial Proteins / immunology*
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Ipomoea batatas / genetics
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Ipomoea batatas / virology
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Plague / microbiology
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Plague / veterinary*
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Plague Vaccine / administration & dosage*
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Plague Vaccine / genetics
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Plague Vaccine / immunology
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Poxviridae / genetics
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Raccoons / virology
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Rodent Diseases / microbiology
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Rodent Diseases / mortality
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Rodent Diseases / prevention & control*
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Sciuridae / microbiology*
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Vaccination
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Vaccines, Synthetic / administration & dosage
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Vaccines, Synthetic / immunology
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Yersinia pestis / immunology*
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Yersinia pestis / pathogenicity
Substances
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Antibodies, Bacterial
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Bacterial Proteins
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Plague Vaccine
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Vaccines, Synthetic
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caf1 protein, Yersinia pestis