Genomic Segmental Polymorphisms in Inbred Mouse Strains

Nat Genet. 2004 Sep;36(9):952-4. doi: 10.1038/ng1417. Epub 2004 Aug 22.

Abstract

By analyzing genomic copy-number differences using high-resolution mouse whole-genome BAC arrays, we uncover substantial differences in regional DNA content between inbred strains of mice. The identification of these apparently common segmental polymorphisms suggests that these differences can contribute to genetic variability and pathologic susceptibility.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Base Sequence
  • Chromosomes, Artificial, Bacterial
  • Gene Dosage*
  • In Situ Hybridization, Fluorescence
  • Mice
  • Mice, Inbred Strains / genetics*
  • Polymorphism, Genetic*