Aptamers meet allostery

Chem Biol. 2004 Aug;11(8):1031-2. doi: 10.1016/j.chembiol.2004.08.003.

Abstract

Engineered RNAs have demonstrated remarkable properties of molecular recognition and allosteric function. Liu and colleagues now report the isolation and in vivo function of a ligand-dependent RNA-based transcription factor that opens wide the door for allosterically controllable aptamers.

Publication types

  • Comment

MeSH terms

  • Allosteric Regulation
  • Allosteric Site
  • Genetic Engineering*
  • Heterocyclic Compounds, 3-Ring / metabolism
  • Ligands
  • RNA / genetics*
  • RNA / metabolism*
  • Rhodamines
  • Transcriptional Activation / genetics*

Substances

  • Heterocyclic Compounds, 3-Ring
  • Ligands
  • Rhodamines
  • tetramethylrosamine
  • RNA