Triterpenoids. Part 21: Oleanolic acid azaderivatives as percutaneous transport promoters

Bioorg Med Chem Lett. 2004 Sep 20;14(18):4723-6. doi: 10.1016/j.bmcl.2004.06.087.

Abstract

Some new oleanolic acid derivatives with lactame and thiolactame structures in the A- or C-ring were prepared and tested as percutaneous transport promoters in vitro. Their activity was comparable with activity of N-dodecylcaprolactame (Azone). A-Thiolactame derivative of methyl oleanolate (13) was the most effective compound.

Publication types

  • Comparative Study

MeSH terms

  • Adjuvants, Pharmaceutic / chemical synthesis
  • Adjuvants, Pharmaceutic / chemistry*
  • Administration, Cutaneous
  • Aza Compounds / chemical synthesis
  • Aza Compounds / chemistry*
  • Biological Transport, Active
  • Humans
  • In Vitro Techniques
  • Lactams / chemical synthesis
  • Lactams / chemistry*
  • Membranes, Artificial*
  • Permeability
  • Progesterone / chemistry
  • Skin Absorption*
  • Structure-Activity Relationship
  • Triterpenes / chemical synthesis
  • Triterpenes / chemistry*

Substances

  • Adjuvants, Pharmaceutic
  • Aza Compounds
  • Lactams
  • Membranes, Artificial
  • Triterpenes
  • oleanonic acid
  • Progesterone