Effect of adjunctive treatment with gamma interferon against Pseudomonas aeruginosa pneumonia in neutropenic and non-neutropenic hosts

Int J Antimicrob Agents. 2004 Sep;24(3):219-25. doi: 10.1016/j.ijantimicag.2004.03.019.

Abstract

To evaluate the adjunctive effect of interferon-gamma (IFN-gamma) in treatment of Pseudomonas aeruginosa pneumonia, neutropenic and non-neutropenic mice received LD(100) of the organism intratracheally, followed by subcutaneous administration of IFN-gamma, ceftazidime (TAZ) or a combination of both agents 2 h post-inoculation. Treatment with IFN-gamma alone showed no significant increase in survival when compared with control. Addition of IFN-gamma to TAZ resulted in no significant change in survival compared with TAZ alone. Survival in TAZ and TAZ + IFN-gamma groups, was significantly higher than in control and IFN-gamma groups. This suggests that adjunctive treatment with IFN-gamma in combination with ceftazidime may not be more beneficial than the antibiotic alone when managing acute P. aeruginosa pneumonia in both immunocompromised and immunocompetent hosts.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adjuvants, Immunologic / administration & dosage
  • Adjuvants, Immunologic / pharmacology
  • Adjuvants, Immunologic / therapeutic use
  • Animals
  • Anti-Bacterial Agents / administration & dosage
  • Anti-Bacterial Agents / pharmacology
  • Anti-Bacterial Agents / therapeutic use
  • Ceftazidime / pharmacology
  • Ceftazidime / therapeutic use*
  • Drug Therapy, Combination
  • Female
  • Immunocompromised Host
  • Injections, Subcutaneous
  • Interferon-gamma / administration & dosage
  • Interferon-gamma / pharmacology
  • Interferon-gamma / therapeutic use*
  • Mice
  • Neutropenia / complications*
  • Pneumonia, Bacterial / complications
  • Pneumonia, Bacterial / drug therapy*
  • Pneumonia, Bacterial / microbiology
  • Pseudomonas Infections / complications
  • Pseudomonas Infections / drug therapy*
  • Pseudomonas aeruginosa / drug effects*
  • Survival Analysis

Substances

  • Adjuvants, Immunologic
  • Anti-Bacterial Agents
  • Interferon-gamma
  • Ceftazidime