Acute phase response in reindeer after challenge with Escherichia coli endotoxin

Comp Immunol Microbiol Infect Dis. 2004 Nov;27(6):413-22. doi: 10.1016/j.cimid.2004.01.005.


The serum concentrations of two acute phase proteins (APPs), haptoglobin (Hp) and serum amyloid-A (SAA), were monitored in reindeer after challenge with endotoxin. Four adult female reindeer received either 0.1 microg/kg Escherichia coli 0111:B4 lipopolysaccharide B or saline solution intravenously. At the second challenge, the treatments were reversed. In addition to the APPs, changes in blood chemistry and rectal temperature were monitored. The endotoxin challenge caused a significant increase in SAA (peak 48 h) and a sharp decrease (8-12 h) of serum iron concentrations in all animals. The mean Hp concentration increased at 8 h and remained elevated until 48 h, but no statistically significant differences were found. This investigation demonstrates that challenge with a single-bolus dose of E. coli endotoxin can activate the acute phase response (APR) and SAA appears to be a more sensitive indicator of the APR than Hp during bacterial infection in reindeer.

MeSH terms

  • Acute-Phase Reaction / blood
  • Acute-Phase Reaction / immunology*
  • Animals
  • Endotoxemia / blood
  • Endotoxemia / immunology
  • Endotoxins / toxicity*
  • Female
  • Haptoglobins / metabolism
  • Iron / blood
  • Reindeer / immunology*
  • Serum Amyloid A Protein / metabolism


  • Endotoxins
  • Haptoglobins
  • Serum Amyloid A Protein
  • endotoxin, Escherichia coli
  • Iron