In vivo activation of the yeast plasma membrane ATPase during nitrogen starvation. Identification of the regulatory domain that controls activation

FEBS Lett. 1992 Apr 6;300(3):271-4. doi: 10.1016/0014-5793(92)80861-a.


Yeast plasma membrane ATPase is activated during nitrogen starvation when a fermentable substrate is present. This activation is due to changes in the Vmax and it is irreversible, independent of protein synthesis and apparently triggered by a decrease in the intracellular pH. It is shown that the ATPase regulatory domain implicated in the activation by fermentable carbon sources is also implicated in activation by nitrogen starvation and by external acidification.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenosine Triphosphatases / chemistry
  • Adenosine Triphosphatases / metabolism*
  • Adenosine Triphosphatases / physiology
  • Cell Membrane / enzymology
  • Enzyme Activation / physiology
  • Fermentation
  • Fungal Proteins / chemistry
  • Fungal Proteins / genetics
  • Fungal Proteins / metabolism*
  • Hydrogen-Ion Concentration
  • Membrane Proteins / chemistry
  • Membrane Proteins / metabolism*
  • Membrane Proteins / physiology
  • Nitrogen / metabolism*
  • Nitrogen / physiology
  • Protein Conformation
  • Saccharomyces cerevisiae / enzymology*
  • Substrate Specificity


  • Fungal Proteins
  • Membrane Proteins
  • Adenosine Triphosphatases
  • Nitrogen