Routine terminations of pregnancy--should we screen for gestational trophoblastic neoplasia?

Lancet. 2004 Aug 21-27;364(9435):705-7. doi: 10.1016/S0140-6736(04)16898-0.

Abstract

After termination of pregnancy for non-medical reasons, the products of conception are often not routinely examined for gestational trophoblastic neoplasia. Between 1995 and 2001 we identified 15 women without and 36 women with a pathological diagnosis of gestational trophoblastic neoplasia at the time of their pregnancy termination. Women without a diagnosis were significantly more likely to have subsequent life-threatening complications of gestational trophoblastic neoplasia (four of 15 vs none of 36; p=0.003), and to require surgical intervention (15 of 15 vs one of 36; p<0.0001) and chemotherapy (nine of 15 vs two of 36; p<0.0001). All women should be screened for gestational trophoblastic neoplasia after termination of pregnancy.

MeSH terms

  • Abortion, Induced*
  • Adolescent
  • Adult
  • Biomarkers, Tumor / analysis*
  • Chorionic Gonadotropin / analysis*
  • Female
  • Gestational Trophoblastic Disease / diagnosis*
  • Gestational Trophoblastic Disease / therapy
  • Humans
  • Pregnancy

Substances

  • Biomarkers, Tumor
  • Chorionic Gonadotropin