Malignant transformation of endometriosis and genetic alterations of K-ras and microsatellite instability

Int J Gynaecol Obstet. 2004 Sep;86(3):371-6. doi: 10.1016/j.ijgo.2004.04.036.


Objectives: To clarify the role of specific genetic alterations in the multi-step process of malignant transformation of endometriosis.

Methods: In cases of ovarian endometrioid carcinoma, we separated regions of normal endometriosis, atypical endometriosis and ovarian endometrioid carcinoma by laser microdissection, and examined K-ras mutation and microsatellite instability in each separated tissue sample.

Results: We detected K-ras mutation and microsatellite instability in endometrioid carcinoma tissue, but not in normal or atypical endometriosis bordering the cancerous region.

Conclusions: The present findings suggest that K-ras mutation and microsatellite instability are associated with malignant transformation from atypical endometriosis to ovarian endometrioid carcinoma.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Carcinoma, Endometrioid / genetics*
  • Carcinoma, Endometrioid / pathology
  • Carcinoma, Endometrioid / surgery
  • Cell Transformation, Neoplastic / genetics*
  • Endometriosis / pathology*
  • Female
  • Genes, ras / genetics*
  • Genomic Instability / genetics*
  • Humans
  • Microsatellite Repeats / genetics
  • Middle Aged
  • Mutation
  • Ovarian Neoplasms / genetics*
  • Ovarian Neoplasms / pathology
  • Ovarian Neoplasms / surgery