Predictive value of indexes of inflammation and hypercoagulability on success of cardioversion of persistent atrial fibrillation

Am J Cardiol. 2004 Aug 15;94(4):508-10. doi: 10.1016/j.amjcard.2004.04.070.


The aim of the present study was to investigate whether success or failure of direct-current cardioversion in patients with persistent atrial fibrillation may be related to indexes of inflammation (as indicated by C-reactive protein and interleukin-6, platelet activation [soluble P-selectin levels], endothelial damage/dysfunction [von Willebrand factor], coagulation cascade [tissue factor and fibrinogen], and rheology [plasma viscosity and hematocrit]). We found that C-reactive protein levels are a predictor of initial cardioversion success, although they failed to predict long-term outcome. Although inflammation may be associated with "permanence" of atrial fibrillation, indexes of platelet activation, endothelial damage/dysfunction, or coagulation showed no relation to the immediate and long-term (2-month) cardioversion outcome.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Atrial Fibrillation / blood
  • Atrial Fibrillation / therapy*
  • C-Reactive Protein / metabolism
  • Electric Countershock*
  • Electrocardiography
  • Female
  • Follow-Up Studies
  • Humans
  • Inflammation Mediators / blood*
  • Male
  • Middle Aged
  • Predictive Value of Tests
  • Prognosis
  • Recurrence
  • Reference Values
  • Retreatment
  • Thrombophilia / blood
  • Thrombophilia / diagnosis*
  • Treatment Outcome


  • Inflammation Mediators
  • C-Reactive Protein