Regional reductions of gray matter volume in familial dyslexia

Neurology. 2004 Aug 24;63(4):742-5. doi: 10.1212/01.wnl.0000134673.95020.ee.

Abstract

An in vivo anatomic study of gray matter volume was performed in a group of familial dyslexic individuals, using an optimized method of voxel-based morphometry. Focal abnormalities in gray matter volume were observed bilaterally in the planum temporale, inferior temporal cortex, and cerebellar nuclei, suggesting that the underlying anatomic abnormalities may be responsible for defective written language acquisition in these subjects.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Cerebellar Nuclei / pathology*
  • Dyslexia / genetics*
  • Dyslexia / pathology
  • Female
  • Humans
  • Image Processing, Computer-Assisted
  • Magnetic Resonance Imaging*
  • Male
  • Middle Aged
  • Neuropsychological Tests
  • Organ Size
  • Temporal Lobe / pathology*