Comparative immunopeptidomics of humans and their pathogens

Proc Natl Acad Sci U S A. 2004 Sep 7;101(36):13268-72. doi: 10.1073/pnas.0404740101. Epub 2004 Aug 23.


Major histocompatibility complex class I molecules present peptides of 8-10 residues to CD8+ T cells. We used 19 predicted proteomes to determine the influence of CD8+ T cell immune surveillance on protein evolution in humans and microbial pathogens by predicting immunopeptidomes, i.e., sets of class I binding peptides present in proteomes. We find that class I peptide binding specificities (i) have had little, if any, influence on the evolution of immunopeptidomes and (ii) do not take advantage of biases in amino acid distribution in proteins other than the concentration of hydrophobic residues in NH(2)-terminal leader sequences.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Biological Evolution
  • CD8-Positive T-Lymphocytes / immunology*
  • Histocompatibility Antigens Class I / metabolism*
  • Humans
  • Ligands
  • Mice
  • Peptide Fragments / immunology*
  • Proteome*


  • Histocompatibility Antigens Class I
  • Ligands
  • Peptide Fragments
  • Proteome