Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 305 (5687), 1157-9

NOBOX Deficiency Disrupts Early Folliculogenesis and Oocyte-Specific Gene Expression

Affiliations

NOBOX Deficiency Disrupts Early Folliculogenesis and Oocyte-Specific Gene Expression

Aleksandar Rajkovic et al. Science.

Abstract

Primordial ovarian follicles in mice form when somatic cells surround individual oocytes. We show that lack of Nobox, an oocyte-specific homeobox gene, accelerates postnatal oocyte loss and abolishes the transition from primordial to growing follicles in mice. Follicles are replaced by fibrous tissue in female mice lacking Nobox in a manner similar to nonsyndromic ovarian failure in women. Genes preferentially expressed in oocytes, including Oct4 and Gdf9, are down-regulated in Nobox-/- mice, whereas ubiquitous genes such as Bmp4, Kit, and Bax remain unaffected. Therefore, Nobox is critical for specifying an oocyte-restricted gene expression pattern essential for postnatal follicle development.

Similar articles

See all similar articles

Cited by 140 PubMed Central articles

See all "Cited by" articles

Publication types

MeSH terms

LinkOut - more resources

Feedback