Globus pallidus calcification in Down syndrome with progressive neurologic deficits

Pediatr Neurol. 1992 Jan-Feb;8(1):72-4. doi: 10.1016/0887-8994(92)90058-7.

Abstract

We report a 10-year-old Down syndrome patient who developed dystonia, choreoathetosis, dysarthria, and dysphagia beginning with hemiparesis. Cranial computed tomography disclosed bilateral calcification in the globus pallidus which resembled a sign of premature aging. Conversely, the clinical course and magnetic resonance imaging findings resembled those of Hallervorden-Spatz syndrome.

Publication types

  • Case Reports

MeSH terms

  • Bone Marrow / pathology
  • Calcinosis / diagnosis*
  • Calcinosis / pathology
  • Child
  • Diagnosis, Differential
  • Down Syndrome / diagnosis*
  • Down Syndrome / pathology
  • Globus Pallidus / pathology*
  • Hemiplegia / diagnosis
  • Hemiplegia / pathology
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Neurologic Examination
  • Neuromuscular Diseases / diagnosis*
  • Neuromuscular Diseases / pathology
  • Pantothenate Kinase-Associated Neurodegeneration / diagnosis*
  • Pantothenate Kinase-Associated Neurodegeneration / pathology
  • Sea-Blue Histiocyte Syndrome / diagnosis
  • Sea-Blue Histiocyte Syndrome / pathology
  • Tomography, X-Ray Computed