A comparison of episodic memory deficits in neuropathologically-confirmed Dementia with Lewy bodies and Alzheimer's disease

J Int Neuropsychol Soc. 2004 Sep;10(5):689-97. doi: 10.1017/S1355617704105043.


Little is known about possible differences in the memory deficits that occur in Dementia with Lewy bodies (DLB) and Alzheimer's disease (AD). We compared 24 autopsy-confirmed DLB and 24 age-, education-, and MMSE-matched autopsy-confirmed AD patients on the California Verbal Learning Test (CVLT) and the Wechsler Memory Scale-Revised Logical Memory subtest. The DLB and AD groups were similarly impaired on CVLT Total Learning (Trials 15) and Long Delayed Free Recall, but the DLB group demonstrated relative improvement in Savings scores and on recognition testing compared to the AD group. Likewise, the patient groups were equally impaired on Logical Memory immediate and delayed recall, but the DLB group's Saving scores were significantly better than those of the AD patients. These results indicate that while both DLB and AD patients exhibit significant memory impairment, the ability to consolidate information may be less severely impaired in DLB patients than in AD patients.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Alzheimer Disease / diagnosis
  • Alzheimer Disease / physiopathology*
  • Autopsy / methods
  • Case-Control Studies
  • Humans
  • Intelligence / physiology
  • Intelligence Tests
  • Lewy Body Disease / diagnosis
  • Lewy Body Disease / physiopathology*
  • Memory Disorders / etiology*
  • Mental Recall / physiology
  • Mental Status Schedule
  • Neurofibrillary Tangles / pathology
  • Neuropsychological Tests
  • Plaque, Amyloid / pathology
  • Verbal Learning / physiology