SAPHO syndrome

Rheum Dis Clin North Am. 1992 Feb;18(1):225-46.


SAPHO (synovitis, acne, pustulosis, hyperostosis, osteitis) syndrome put together osteoarticular lesions described separately under numerous denominations, such as multifocal osteomyelitis, pustulotic arthroosteitis, acne rheumatism. The association of sterile inflammatory bone lesions and neutrophilic skin eruptions is the cornerstone of this new syndrome, which also has links with spondyloarthropathies and plain psoriasis.

Publication types

  • Review

MeSH terms

  • Acne Vulgaris / complications*
  • Humans
  • Hyperostosis / complications*
  • Osteitis / complications*
  • Psoriasis / complications*
  • Syndrome
  • Synovitis / complications*