No evidence for germline mutations of the LKB1/STK11 gene in familial pancreatic carcinoma

Cancer Lett. 2004 Oct 8;214(1):63-8. doi: 10.1016/j.canlet.2004.06.012.

Abstract

Familial pancreatic cancer (FPC) (approximately 3% of all cases) has not been linked to defects in any specific gene. Germline inactivation of the gene LKB1/STK11 have been shown to cause Peutz-Jeghers syndrome (PJS) associated with a approximately 100-fold higher risk for the development of pancreatic cancer. We have analysed 39 index patients from European FPC families for mutations of LKB1/STK11 by sequencing of their DNA. No germline mutation was found within the complete coding region. Therefore, our results indicate that LKB1/STK11 is not altered in the germline of patients with hereditary pancreatic cancer.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Carcinoma / genetics*
  • DNA Mutational Analysis
  • Female
  • Genetic Predisposition to Disease*
  • Germ-Line Mutation*
  • Humans
  • Male
  • Middle Aged
  • Pancreatic Neoplasms / genetics*
  • Pedigree
  • Protein-Serine-Threonine Kinases / genetics*

Substances

  • STK11 protein, human
  • Protein-Serine-Threonine Kinases