Drug-induced and iatrogenic infiltrative lung disease

Clin Chest Med. 2004 Sep;25(3):479-519, vi. doi: 10.1016/j.ccm.2004.05.006.


At present more than 350 drugs are known to cause injury of the lung parenchyma,upper and lower airways, pulmonary circulation, pleura, mediastinum, lymph nodes,and neuromuscular system. Infiltrative lung disease (ILD) is the most common pattern of drug-induced injury. This article, which is clinically oriented rather than drug oriented, reviews the patterns of ILD produced by therapeutic drugs and radiation therapy.

Publication types

  • Review

MeSH terms

  • Amiodarone / adverse effects
  • Anti-Arrhythmia Agents / adverse effects
  • Drug-Related Side Effects and Adverse Reactions
  • Humans
  • Iatrogenic Disease*
  • Lung Diseases / chemically induced*
  • Lung Diseases / diagnosis
  • Lung Diseases / pathology
  • Methotrexate / adverse effects*
  • Pneumonia / chemically induced
  • Pulmonary Alveoli / pathology
  • Pulmonary Edema / chemically induced
  • Sarcoidosis, Pulmonary / chemically induced


  • Anti-Arrhythmia Agents
  • Amiodarone
  • Methotrexate