Oolong tea increases plasma adiponectin levels and low-density lipoprotein particle size in patients with coronary artery disease

Diabetes Res Clin Pract. 2004 Sep;65(3):227-34. doi: 10.1016/j.diabres.2004.01.003.

Abstract

Background: Oolong tea has been studied for its effect on cardiovascular disease and obesity. Plasma adiponectin levels are reduced in obesity, in patients with type 2 diabetes mellitus and in coronary artery disease (CAD).

Objective: To investigate prospectively, whether intake of Oolong tea influences plasma adiponectin levels, low-density lipoprotein (LDL) particle size, total cholesterol, high-density lipoprotein (HDL) cholesterol, LDL cholesterol, serum triglyceride and plasma glucose levels in patients with CAD.

Methods: Twenty two patients in our study consumed Oolong tea (1000 ml) or water for 1 month in our randomized cross-over study design.

Results: There was a significant difference in plasma adiponectin levels before and after 1 month intake of Oolong tea (6.26 +/- 3.26 microg/ml versus 6.88 +/- 3.28 microg/ml, P < 0.05), and in plasma level LDL particle size (25.02+/-0.67 nm versus 25.31+/-0.60 nm, P < 0.01). The water-consuming control group showed no changes (6.28+/-3.28 microg/ml versus 6.23+/-3.21 microg/ml) in adiponectin levels or LDL particle sizes (25.03+/-0.70 nm versus 25.02+/-0.72 nm). We also observed a significant difference in hemoglobin A1c levels (7.23 +/- 4.45% versus 6.99 +/- 4.30%, P < 0.05) before and after intake of Oolong tea.

Conclusion: Oolong tea may have beneficial effects on the progression of atherosclerosis in patients with CAD.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adiponectin
  • Blood Glucose / analysis
  • Cholesterol / blood
  • Cholesterol, HDL / blood
  • Cholesterol, LDL / blood
  • Collagen / blood
  • Coronary Disease / blood*
  • Cross-Over Studies
  • Diabetes Mellitus, Type 2 / blood
  • Female
  • Glycated Hemoglobin A / metabolism
  • Humans
  • Intercellular Signaling Peptides and Proteins / blood*
  • Lipoproteins, LDL / blood
  • Male
  • Middle Aged
  • Particle Size
  • Prospective Studies
  • Tea* / chemistry
  • Triglycerides / blood

Substances

  • Adiponectin
  • Blood Glucose
  • Cholesterol, HDL
  • Cholesterol, LDL
  • Glycated Hemoglobin A
  • Intercellular Signaling Peptides and Proteins
  • Lipoproteins, LDL
  • Tea
  • Triglycerides
  • Collagen
  • Cholesterol