Schizophrenia genetics: dysbindin under the microscope

Trends Neurosci. 2004 Sep;27(9):516-9. doi: 10.1016/j.tins.2004.06.004.


It is well established that genetic factors strongly contribute to the susceptibility of an individual to schizophrenia. Straub, Kendler and colleagues have published the first of several articles demonstrating a genetic association between schizophrenia and the gene encoding the dystrobrevin-binding protein dysbindin. Although no mutations in the dysbindin gene have been found, the recent identification of a specific risk haplotype in independent samples provides further evidence that dysbindin is a possible schizophrenia susceptibility gene.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Carrier Proteins / genetics*
  • Carrier Proteins / metabolism
  • Dysbindin
  • Dystrophin-Associated Proteins
  • Genetic Predisposition to Disease*
  • Humans
  • Schizophrenia / genetics*


  • Carrier Proteins
  • DTNBP1 protein, human
  • Dysbindin
  • Dystrophin-Associated Proteins